Synthesis and a combined experimental/theoretical structural study of a comprehensive set of Pd/NHC complexes with<i>o</i>-,<i>m</i>-, and<i>p</i>-halogen-substituted aryl groups (X = F, Cl, Br, CF<sub>3</sub>)
Roman O. Pankov, Darya O. Prima, Alexander Yu. Kostyukovich, Mikhail E. Minyaev, Valentine P. Ananikov
Abstract
A complete series of free NHC ligands and Pd/NHC complexes with –F, –Cl, –Br, and –CF 3 substituents at the o -, m -, and p -positions of the aryl ring were synthesized and characterized. An increase of catalytic activity was observed in the Mizoroki–Heck reaction.
Topics & Concepts
ArylHalogenChemistryCatalysisRing (chemistry)Medicinal chemistryPalladiumStereochemistryOrganic chemistryAlkylN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis