MST and TRIC Technology to Reliably Study PROTAC Binary and Ternary Binding in Drug Development
Tanja Bartoschik, Andreas Zoephel, Klaus Rumpel, Alessio Ciulli, Charles Heffern
Topics & Concepts
Ternary complexTernary operationMicroscale thermophoresisDrug discoverySmall moleculeCooperativityComputational biologyMechanism (biology)Function (biology)ChemistryNanotechnologyBiological systemMaterials scienceBiologyComputer scienceBiochemistryPhysicsGeneticsQuantum mechanicsEnzymeProgramming languageProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments