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Redox Neutral Radical-Relay Cobalt Catalysis toward C–H Fluorination and Amination

Peng Guo, Yuanyuan Li, Xianggui Zhang, Jun‐Fa Han, Yi Yu, Jun Zhu, Ke‐Yin Ye

2020Organic Letters65 citationsDOI

Abstract

-fluoroamides featuring the in situ formed cobalt fluorides as the latent radical fluorinating agents is reported. Moreover, the reactivity of such a cobalt catalysis could be diverted from C-H fluorination to amination by engineering substrates' conformational flexibility. Preliminary mechanistic studies (UV-vis spectroscopy, cyclic voltammetry studies and DFT calculations, etc.) support the reaction proceeding a redox neutral radical-relay mechanism.

Topics & Concepts

ChemistryAminationCobaltRelayRedoxCatalysisRadicalPhotochemistryCombinatorial chemistryOrganic chemistryPhysicsQuantum mechanicsPower (physics)Fluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds