Molecular Iodine-Catalyzed Synthesis of Imidazo[1,2-<i>a</i>]Pyridines: Screening of Their <i>In Silico</i> Selectivity, Binding Affinity to Biological Targets, and Density Functional Theory Studies Insight
Deepika Geedkar, Ashok Kumar, Pratibha Sharma
Abstract
testing of synthesized derivatives as potent inhibitors with an improved pharmacological profile against farnesyl diphosphate synthase, phosphodiesterase III, CXCR4, and GABAa receptor agonists.
Topics & Concepts
ChemistryLipinski's rule of fiveDensity functional theoryIn silicoCombinatorial chemistryPyridineCatalysisSelectivityReactivity (psychology)Computational chemistryOrganic chemistryBiochemistryAlternative medicineMedicineGenePathologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Reactivity of Heterocycles