A series of ligustrazine platinum(<scp>iv</scp>) complexes with potent anti-proliferative and anti-metastatic properties that exert chemotherapeutic and immunotherapeutic effects
Yan Chen, Linming Li, Zhifang Liu, Meifeng Liu, Qingpeng Wang
Abstract
A series of ligustrazine platinum( iv ) complexes were developed, which displayed potent anti-proliferative and anti-metastatic activities by causing DNA damage, mitochondrial damage, and pro-death autophagy and activating immune response.
Topics & Concepts
ChemistryPlatinumPharmacologyCombinatorial chemistryCancer researchMedicineBiochemistryCatalysisMetal complexes synthesis and propertiesCancer therapeutics and mechanismsCancer Mechanisms and Therapy