Phloretin attenuation of hepatic steatosis <i>via</i> an improvement of mitochondrial dysfunction by activating AMPK-dependent signaling pathways in C57BL/6J mice and HepG2 cells
Lin Han, Yao Zhang, Jia Li, Yao Xiao, Mei Lü, Yunlong Li, Min Wang
Abstract
promoting fatty acid β-oxidation (FAO). This biological activity of phloretin was closely related to its capacity to improve mitochondrial dysfunction, including the promotion of mitochondrial biosynthesis and inhibition of mitochondrial swelling through the AMPK-dependent SIRT1/PGC-1α and SIRT3/CypD signaling pathways, respectively. These results demonstrate that phloretin effectively improves mitochondrial function and ameliorates HFD-induced hepatic steatosis through an AMPK-dependent signaling pathway.
Topics & Concepts
PhloretinSteatosisAMPKChemistryBeta oxidationBiochemistryMitochondrionFatty liverEndocrinologyPharmacologyInternal medicineBiologyFatty acidMedicineProtein kinase AEnzymeDiseaseAdipose Tissue and MetabolismLiver Disease Diagnosis and TreatmentSirtuins and Resveratrol in Medicine