A Streamlined, Green, and Sustainable Synthesis of the Anticancer Agent Erdafitinib
Vani Singhania, Chandler B. Nelson, Maya Reamey, Emile Morin, Rahul D. Kavthe, Bruce H. Lipshutz
Abstract
Erdafitinib, an anticancer drug, was synthesized in a three-step two-pot sequence involving ppm levels of Pd catalyst run under aqueous micellar conditions enabled by a biodegradable surfactant. This process features both pot- and time-economies and eliminates egregious organic solvents and toxic reagents associated with existing routes.
Topics & Concepts
ChemistryReagentCatalysisCombinatorial chemistryAqueous mediumAqueous solutionAnticancer drugPulmonary surfactantNuclear chemistryDrugOrganic chemistryPharmacologyBiochemistryMedicineNanomaterials for catalytic reactionsAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysis