Manifesting the Dasatinib-gallic acid co-amorphous system to augment anticancer potential: Physicochemical characterization, in silico molecular simulation, ex vivo permeability, and in vitro efficacy
Tanmoy Kanp, Anish Dhuri, Mayur Aalhate, Srushti Mahajan, Sharon Munagalasetty, Sunil Kumar Sah, Santanu Kaity, B. Sharan Sharma, Vasundhra Bhandari, Pankaj Kumar Singh
Topics & Concepts
DasatinibGallic acidEx vivoBioavailabilitySolubilityChemistryIn vivoPharmacologyAmorphous solidNuclear chemistryIn vitroTyrosine kinaseOrganic chemistryBiochemistryMedicineBiologyAntioxidantSignal transductionBiotechnologyMetal complexes synthesis and propertiesSynthesis and biological activitySynthesis of Tetrazole Derivatives