Lichen planus pemphigoides successfully treated with dupilumab

Abstract

Lichen planus pemphigoides (LPP) is a rare, autoimmune, immunobullous dermatosis characterized by overlapping clinical features between lichen planus and bullous pemphigoid (BP). Most cases are idiopathic, but it has been associated with angiotensin-converting enzyme inhibitors and viral infections. Because lichenoid lesions typically precede the bullae, it has been hypothesized that the lichenoid inflammation leads to epitope spreading and ultimately antibody formation against the basement membrane proteins.

Topics & Concepts