Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation
Shuai‐Jiang Liu, Qian Zhao, Cheng Peng, Qing Mao, Fengbo Wu, Fenghua Zhang, Quansheng Feng, Gu He, Bo Han
Topics & Concepts
ChemistryOxindoleGlutathione peroxidaseCell growthChemical synthesisPeroxidaseGlutathioneBiochemistryEnzymeStereochemistryPharmacologyCancer researchIn vitroCatalysisBiologyMedicineInflammatory mediators and NSAID effectsEstrogen and related hormone effectsSynthesis and biological activity