PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity
Jacqueline Moebius, Rajan Guha, Mary Peterson, Kaveh Abdi, Jeff Skinner, Shanping Li, Gunjan Arora, Boubacar Traoré, Sumati Rajagopalan, Eric O. Long, Peter D. Crompton
Abstract
Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood. PD-1 is an inhibitory receptor that regulates T cell function, but a role for PD-1 in regulating NK cell function is only beginning to emerge.
Topics & Concepts
CytotoxicityBiologyAntibody-dependent cell-mediated cytotoxicityMalariaAntibodyImmunologyNatural killer cellIn vitroBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses