Use of Early Intrathecal Therapy to Manage High-Grade Immune Effector Cell-Associated Neurotoxicity Syndrome
Joanna Zurko, Bryon D. Johnson, Emilie Aschenbrenner, Timothy S. Fenske, Mehdi Hamadani, Parameswaran Hari, Nirav N. Shah
Abstract
This case series describes the use of early intrathecal steroid administration to manage high-grade and steroid-refractory immune effector cell-associated neurotoxicity syndrome among patients with B-cell non-Hodgkin lymphoma.
Topics & Concepts
MedicineNeurotoxicityEffectorImmune systemLymphomaIntrathecalImmunologyOncologyInternal medicineToxicitySurgeryCAR-T cell therapy researchCancer Treatment and PharmacologyNeuroblastoma Research and Treatments