MOTS-c reduces myostatin and muscle atrophy signaling
Hiroshi Kumagai, Ana R. Coelho, Junxiang Wan, Hemal H. Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J. Oliveira, Pinchas Cohen, Su‐Jeong Kim
Abstract
MOTS-c, a mitochondrial-derived peptide reduces high-fat-diet-induced muscle atrophy signaling by reducing myostatin expression. The CK2-PTEN-mTORC2-AKT-FOXO1 pathways play key roles in MOTS-c action on myostatin expression.
Topics & Concepts
MyostatinPTENAtrophyFOXO1Muscle atrophyProtein kinase BPI3K/AKT/mTOR pathwaySignal transductionmTORC2Internal medicineCancer researchEndocrinologyBiologyMedicineCell biologyMuscle hypertrophymTORC1GDF15 and Related BiomarkersMuscle Physiology and DisordersNutrition and Health in Aging