Erythrocyte membrane-camouflaged Prussian blue nanocomplexes for combinational therapy of triple-negative breast cancer
Simin Chen, Jialong Fan, Feng Xiao, Qin Yan, Ying Long, Liqin Yuan, Bin Liu
Abstract
PDT/PTT was enhanced, by which the cell viability was reduced to 21.4%, which is lower than the 55.6% (PDT) and 66.7% (PTT) of PMRCR NPs with a single laser treatment. By modeling 4T1 tumor-bearing mice, the combined PDT/PTT of PMRCR NPs greatly inhibited tumor growth, and after 20 days, a tumor inhibition rate of 92.9% was achieved. This work provides a promising strategy by developing TME-reprogrammed multifunctional nanocomplexes to enhance PDT/PTT antitumor efficacy.
Topics & Concepts
Prussian blueTriple-negative breast cancerCancer researchMedicineBreast cancerChemistryCancerInternal medicinePhysical chemistryElectrochemistryElectrodeNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisGold and Silver Nanoparticles Synthesis and Applications