Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer
Tsung‐Ming Chang, Miao‐Ching Chi, Yao‐Chang Chiang, Chieh‐Mo Lin, Mei-Ling Fang, Chiang‐Wen Lee, Ju‐Fang Liu, Yu Ru Kou
Abstract
This study demonstrated the potent anti-cancer effects of naringenin on lung cancer cells, thereby providing valuable insights for developing small-molecule drugs that can induce cell cycle arrest, apoptosis, and autophagic cell death.
Topics & Concepts
NaringeninChemistryApoptosisAutophagyViability assayProgrammed cell deathCell biologyCancer cellCancer researchMolecular biologyBiologyCancerBiochemistryGeneticsAntioxidantFlavonoidAutophagy in Disease and TherapyCancer Mechanisms and TherapyFerroptosis and cancer prognosis