State of the Art in Crystallization‐Induced Diastereomer Transformations
Andrej Kolarovič, Pavol Jakubec
Abstract
Abstract Crystallization‐induced diastereomer transformations (CIDT) enable isolation of the target compounds in high enantio‐ and diastereomeric purities and with up to quantitative yields simply by filtration. Numerous inspiring examples of this appealing synthetic strategy reported over the last fifteen years are reviewed. Important observations along with aspects to consider when designing CIDT experiments are discussed. magnified image
Topics & Concepts
DiastereomerChemistryCrystallizationFiltration (mathematics)Combinatorial chemistryStereochemistryOrganic chemistryPure mathematicsMathematicsMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyComputational Drug Discovery Methods