The Quorum-Sensing Inhibitor Furanone C-30 Rapidly Loses Its Tobramycin-Potentiating Activity against Pseudomonas aeruginosa Biofilms during Experimental Evolution
Mona Bové, Xuerui Bao, Andrea Saß, Aurélie Crabbé, Tom Coenye
Abstract
The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to combat antibiotic resistance. QSI reduce the virulence of a pathogen without killing it and it is claimed that resistance to such compounds is less likely to develop, although there is a lack of experimental data supporting this hypothesis.
Topics & Concepts
Pseudomonas aeruginosaQuorum sensingTobramycinBiofilmMicrobiologyPseudomonadaceaeChemistryPseudomonadalesBiologyBacteriaGeneticsBacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyAntimicrobial Peptides and Activities