An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín‐Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi
Abstract
cells. Collectively, these results unveil a robust apoptotic caspase network that is activated in parallel to GSDMD-mediated plasma membrane permeabilization and safeguards cell death induction in pyroptotic macrophages.
Topics & Concepts
PyroptosisInflammasomeCell biologyProgrammed cell deathCaspase 1ApoptosisCaspaseCaspase 8NLRP1BiologyInflammationChemistryImmunologyBiochemistryInflammasome and immune disordersHeme Oxygenase-1 and Carbon Monoxide