Surgical Approaches to Retinal Gene Therapy: 2025 Update
Milin J. Patel, Sohum Sheth, Jessica Mar, Ninel Z. Gregori, Jesse D. Sengillo
Abstract
Gene therapy offers a promising new frontier in the treatment of inherited and acquired retinal disease. This review describes the current surgical delivery approaches for gene therapy to the retina-subretinal, suprachoroidal, and intravitreal-and provides an update on the state of the art for each method in 2025.
Topics & Concepts
Genetic enhancementRetinalGeneMedicineBioinformaticsGene deliveryComputational biologyRetinal degenerationRetinaCurrent (fluid)Genome editingBiologyComputer scienceSurgical proceduresRetinal Development and DisordersRetinal and Macular SurgeryRetinal Diseases and Treatments