Thianthrenium-Enabled Phosphorylation of Aryl C–H Bonds via Electron Donor–Acceptor Complex Photoactivation
Hao Xu, Xufeng Li, Yuzheng Dong, Shaoxiong Ji, Junze Zuo, Jian Lv, Daoshan Yang
Abstract
An efficient strategy for the preparation of aryl phosphonates via blue-light-promoted single electron transfer process of an EDA complex between phosphites and thianthrenium salts has been demonstrated. The corresponding substituted aryl phosphonates were obtained in good to excellent yields, and the byproduct thianthrene can be recovered and reused in quantity. This developed method realizes the construction of aryl phosphonates through the indirect C-H functionalization of arenes, which has potential application value in drug discovery and development.
Topics & Concepts
ChemistryArylCombinatorial chemistrySurface modificationElectron donorElectron acceptorAcceptorElectron transferThianthrenePhotochemistryCatalysisOrganic chemistryPhysical chemistryAlkylPhysicsCondensed matter physicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods