TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism
Chia‐En Wong, Lee‐Way Jin, Yuan-Ping Chu, Wei‐Yen Wei, Pei‐Chuan Ho, Kuen‐Jer Tsai
Abstract
Our study elucidates the interplay between TDP-43 and neuronal mRNP granules in normal physiology and TDP-43 proteinopathy in the regulation of local protein translation and mRNA metabolism in the postsynaptic compartment.
Topics & Concepts
Postsynaptic potentialCell biologyTranslation (biology)Messenger RNARibonucleoproteinGranule (geology)NeuroscienceRNAChemistryBiologyBiochemistryGeneReceptorPaleontologyRNA Research and SplicingNeurogenetic and Muscular Disorders ResearchGenetic Neurodegenerative Diseases