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Hydrobismuthation: Insertion of Unsaturated Hydrocarbons into the Heaviest Main Group Element Bond to Hydrogen

Kristian L. Mears, Gia-Ann Nguyen, Bronson Ruiz, Annika Lehmann, Jonah Nelson, James C. Fettinger, Heikki M. Tuononen, Philip P. Power

2024Journal of the American Chemical Society14 citationsDOIOpen Access PDF

Abstract

High Resolution Image Download MS PowerPoint Slide The bismuth hydride (2,6-Mes 2 H 3 C 6 ) 2 BiH ( 1, Mes = 2,4,6-trimethylphenyl), which has a Bi–H 1 H NMR spectroscopic signal at δ = 19.64 ppm, was reacted with phenylacetylene at 60 °C in toluene to yield [(2,6-Mes 2 C 6 H 3 ) 2 BiC(Ph)=CH 2 ] ( 2 ) after 15 min. Compound 2 was characterized by 1 H, 13 C NMR, and UV–vis spectroscopy, single crystal X-ray crystallography, and calculations employing density functional theory. Compound 2 is the first example of a hydrobismuthation addition product and displays Markovnikov regioselectivity. Computational methods indicated that it forms via a radical mechanism with an associated Gibbs energy of activation of 91 kJ mol –1 and a reaction energy of −90 kJ mol –1 .

Topics & Concepts

ChemistryDensity functional theoryRegioselectivityHydrideTolueneYield (engineering)Hydrogen bondMarkovnikov's rulePhenylacetyleneProton NMRCrystallographyMedicinal chemistryComputational chemistryMoleculeHydrogenStereochemistryOrganic chemistryCatalysisMaterials scienceMetallurgySynthesis and characterization of novel inorganic/organometallic compoundsOrganoboron and organosilicon chemistryOrganometallic Complex Synthesis and Catalysis