An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion
Bethany Vaughn, Kevin Voth, Christopher T. D. Price, Snake Jones, Mateja Ožanić, Marina Šantić, Mirosław Cygler, Yousef Abu Kwaik
Abstract
Intracellular proliferation of Legionella pneumophila within a vacuole in human alveolar macrophages is essential for manifestation of Legionnaires’ pneumonia. Intravacuolar growth of the pathogen is totally dependent on remodeling the L. pneumophila -containing vacuole (LCV) by the ER and on its evasion of the endosomal-lysosomal degradation pathway.
Topics & Concepts
Legionella pneumophilaVacuoleMicrobiologyEffectorEndosomeLegionellaIntracellularPathogenAutophagyLysosomeBiologyChemistryCell biologyBacteriaBiochemistryEnzymeCytoplasmApoptosisGeneticsLegionella and Acanthamoeba researchNeutrophil, Myeloperoxidase and Oxidative MechanismsHeme Oxygenase-1 and Carbon Monoxide