A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities
Juan Wang, Boqiang Liang, Yi‐Ling Chen, Jasper Fuk‐Woo Chan, Shuofeng Yuan, Hui Ye, Linlin Nie, Jiao Zhou, Yi Wu, Meixian Wu, Lina Huang, Jing An, Arieh Warshel, Kwok-Yung Yuen, Aaron Ciechanover, Ziwei Huang, Yan Xu
Topics & Concepts
ChemistryProteasomeStructure–activity relationshipMoietyLead compoundChemical synthesisStereochemistryBiological activityBiochemistryPharmacologyIn vitroBiologyUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and Therapy