Enhanced Doxorubicin Delivery in Folate-Overexpressed Breast Cancer Cells Using Mesoporous Carbon Nanospheres
Kandasamy Vinothini, Sathish Sundar Dhilip Kumar, Heidi Abrahamse, Mariappan Rajan
Abstract
. Moreover, DOX/Ox-MPCNP-Cys-PAsp-FA-treated cells displayed efficient cell apoptosis and cell death in flow cytometry analysis. The mitochondrial fragmentation and nucleus damages were further confirmed by fluorescence microscopy. Thus, the approach used to construct the DOX/Ox-MPCNP-Cys-PAsp-FA carrier provides excellent opportunities for the targeted treatment of breast cancer.
Topics & Concepts
DoxorubicinNanocarriersDrug deliveryCancer cellMesoporous silicaFlow cytometryChemistryBiophysicsMaterials scienceNanotechnologyNuclear chemistryBiochemistryCancerMolecular biologyMesoporous materialMedicineBiologyChemotherapyInternal medicineCatalysisSurgeryGraphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryCarbon and Quantum Dots Applications