Reductive evolution of virulence repertoire to drive the divergence between community- and hospital-associated methicillin-resistant <i>Staphylococcus aureus</i> of the ST1 lineage
Marina Farrel Côrtes, Ana Maria Nunes Botelho, Paula Terra Bandeira, William Mouton, Cédric Badiou, Michèle Bes, Nicholas Costa Barroso Lima, André E. R. Soares, Rangel Celso Souza, Luiz Gonzaga Paula de Almeida, Patrícia Martins-Simões, Ana Tereza Ribeiro de Vasconcelos, Marisa Nicolás, Frédéric Laurent, Paul J. Planet, Agnes Marie Sá Figueiredo
Abstract
IV strains have adapted to the hospital setting by reducing virulence and gaining the ability to persist and survive inside host cells. Possibly, these evolutionary strategies may balance the biologic cost of retaining multiple antibiotic resistance genes.
Topics & Concepts
BiologyVirulenceLineage (genetic)Staphylococcus aureusMicrobiologyRepertoireMethicillin-resistant Staphylococcus aureusDivergence (linguistics)VirologyGeneticsGeneBacteriaLinguisticsAcousticsPhilosophyPhysicsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology