Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity
Ruyu Wang, Xuwen Chen, Hongtao Li, Xixiang Chen, Donghui Sun, Danmei Yu, Jiani Lu, Yuanyuan Xie, Qian Zhang, Jianrong Xu, Weidong Zhang, Hongzhuan Chen, Shunying Liu, Lili Chen
Topics & Concepts
ChemistryCurcuminSalvia miltiorrhizaPharmacologyVero cellCoronavirusProteaseDrug discoveryBiochemistryHEK 293 cellsIn vitroEnzymeCoronavirus disease 2019 (COVID-19)BiologyMedicineInfectious disease (medical specialty)ReceptorDiseasePathologyAlternative medicineTraditional Chinese medicinePharmacological Effects of Natural CompoundsTraditional Chinese Medicine AnalysisComputational Drug Discovery Methods