Design, Synthesis, Dynamic Docking, Biochemical Characterization, and <i>in Vivo</i> Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
José M. Arencibia, Nicoletta Brindani, Sebastián Franco-Ulloa, Michela Nigro, Jissy Akkarapattiakal Kuriappan, Giuliana Ottonello, Sine Mandrup Bertozzi, Maria Summa, Stefania Girotto, Rosalia Bertorelli, Andrea Armirotti, Marco De Vivo
Abstract
tumor models.
Topics & Concepts
ChemistryIn vivoDU145PharmacokineticsEtoposideLipinski's rule of fiveTopoisomeraseDocking (animal)HeLaCombinatorial chemistryPharmacologyIn vitroIn silicoBiochemistryCancer cellCancerBiologySurgeryNursingInternal medicineMedicineBiotechnologyChemotherapyGeneLNCaPCancer therapeutics and mechanismsLung Cancer Research StudiesNeuroblastoma Research and Treatments