Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition
Yuichi Suzuki, Haruno Onuma, Risa Sato, Yusuke Sato, Akari Hashiba, Masatoshi Maeki, Manabu Tokeshi, Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama–Kohara, Hideyoshi Harashima
Topics & Concepts
CRISPRcccDNAGenome editingRibonucleoproteinCas9OligonucleotideHepatitis B virusDNAVirologyGene deliveryBiologyComputational biologyGuide RNAChemistryVirusMolecular biologyGenetic enhancementGeneRNAGeneticsHBsAgCRISPR and Genetic EngineeringMosquito-borne diseases and controlVirus-based gene therapy research