Nuciferine prevents obesity by activating brown adipose tissue
Chunlong Yan, Yang Zhan, Shouli Yuan, Yujing Cao, Yi Chen, Meng Dong, Hanlin Zhang, Li Chen, Rui Jiang, Wenjun Liu, Wanzhu Jin, Yuanyuan Huang
Abstract
) expression, which is a key gene involved in mitochondrial biogenesis promoter activity, by directly binding to RXRA. Furthermore, RXRA knockdown abolished expression of the nuciferine-induced mitochondrial and thermogenesis-related gene in primary brown adipocytes. In summary, we found that LLE and nuciferine have a notable effect on BAT activation and highlight the potential applications of the main component of LLE in preventing obesity and treating metabolic disorders.
Topics & Concepts
Brown adipose tissueAdipose tissueObesityEndocrinologyInternal medicineBiologyMedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses