Catalyst- and solvent-free aminolysis of the asymmetric derivatives of Evans’ chiral <i>N</i>-acyloxazolidinones: enantioselective synthesis of chiral amides and its applications
Hui-Rong Lu, Hui Geng, Guan-Tian Ding, Pei‐Qiang Huang
Abstract
We report a convenient method for the aminolysis of N -acyloxazolidinone-derived asymmetric products and the direct conversion of the resulting secondary amides into diverse classes of compounds.
Topics & Concepts
Enantioselective synthesisAminolysisCatalysisChemistrySolventOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic ChemistryChemical Synthesis and Analysis