Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives
Yohei Saito, Yukako Taniguchi, Sachika Hirazawa, Yuta Miura, Hiroyuki Tsurimoto, Tomoki Nakayoshi, Akifumi Oda, Ernest Hamel, Katsumi Yamashita, Masuo Goto, Kyoko Nakagawa‐Goto
Topics & Concepts
ChemistryChromoneBenzothiopheneStereochemistrySubstituentRing (chemistry)Alkoxy groupTopoisomeraseCell cycleStructure–activity relationshipBiological activityFlavonolsFlavonesDNAApoptosisIn vitroFlavonoidBiochemistryOrganic chemistryAlkylAntioxidantThiopheneChromatographySynthesis of Organic CompoundsSynthesis and biological activityBioactive Compounds and Antitumor Agents