Activatable photoacoustic/fluorescent dual-modal probe for monitoring of drug-induced liver hypoxia <i>in vivo</i>
Xiaopeng Fan, Tian‐Bing Ren, Wen Yang, Xiaobing Zhang, Lin Yuan
Abstract
Effective monitoring of liver hypoxia is crucial for warning of drug-induced liver injury. Here, a novel photoacoustic/fluorescent dual-modal probe was rationally developed to image isoniazid-induced liver hypoxia through detecting nitroreductase.
Topics & Concepts
NitroreductaseFluorescenceHypoxia (environmental)In vivoPhotoacoustic imaging in biomedicineDrugLiver injuryChemistryPharmacologyMedicineBiochemistryBiologyProdrugOpticsOxygenPhysicsOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsSulfur Compounds in BiologyPhotodynamic Therapy Research Studies