Epigenetic silencing of GCH1promotes hepatocellular carcinoma growth by activating superoxide anion-mediated ASK1/p38 signaling via inhibiting tetrahydrobiopterin de novo biosynthesis
Guo‐Chao Zhong, Zhibo Zhao, Yao Cheng, Yunbing Wang, Chan Qiu, Lin‐Hong Mao, Jie‐Jun Hu, Dong Cai, Yan Liu, Jianping Gong, Shengwei Li
Topics & Concepts
Gene silencingTetrahydrobiopterinSuperoxideSignal transductionCancer researchBiologyCell biologyp38 mitogen-activated protein kinasesChemistryMAPK/ERK pathwayBiochemistryNitric oxide synthaseEnzymeGeneEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchCancer, Hypoxia, and Metabolism