A Manganese-independent Aldolase Enables Staphylococcus aureus To Resist Host-imposed Metal Starvation
Paola K. Párraga Solórzano, Talina S. Bastille, Jana N. Radin, Thomas E. Kehl‐Fie
Abstract
, which functionally substitutes for the metal-dependent isoenzyme FbaA and enables S. aureus to survive host-imposed manganese starvation. Unexpectedly, and differing from most characterized metal-dependent aldolases, FbaA requires manganese for activity. Cumulatively, these findings reveal a new mechanism for overcoming nutritional immunity as well as the cofactor plasticity of even well-characterized metalloenzyme families.
Topics & Concepts
Staphylococcus aureusMicrobiologyAldolase AVirulenceBiologyBacteriaStaphylococcal infectionsBiochemistryChemistryEnzymeGeneGeneticsAntimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyEnzyme Structure and Function