Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis
Keitaro Hayashi, Yoshimasa Nakazato, Motoshi Ouchi, Tomoe Fujita, Hitoshi Endou, Masayuki Chida
Topics & Concepts
Lactate dehydrogenase AApoptosisLactate dehydrogenaseCancer researchPI3K/AKT/mTOR pathwayViability assayCell cultureChemistryCell growthDownregulation and upregulationImmunohistochemistryCancerCarcinomaCellBiologyPharmacologyBiochemistryInternal medicineMedicineImmunologyEnzymeGeneGeneticsAmino Acid Enzymes and MetabolismCancer, Hypoxia, and MetabolismCancer Research and Treatments