Novel 1,2,5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells
Jagadeesha Gullahalli Swathantraiah, Sudhanva M. Srinivasa, Anil Kumar Belagal Motatis, Akshay Uttarkar, Shwetha Bettaswamygowda, Sridhar Bilgumba Thimmaiah, Vidya Niranjan, Shobith Rangappa, Rangappa Kanchugarakoppal Subbegowda, Thimmegowda Naraganahalli Ramegowda
Abstract
treatment was also unveiled by apoptotic analysis and immunofluorescence imaging. Cell cycle analysis distribution confirms the accumulation of cells in the S-phase in a dose-dependent manner.
Topics & Concepts
HeLaJurkat cellsApoptosisCancer cellTrypan blueCytotoxic T cellChemistryCancerCell cycleCell biologyCell cultureViability assayMTT assayMolecular biologyCancer researchBiologyCellBiochemistryT cellImmunologyIn vitroGeneticsImmune systemSynthesis and biological activityClick Chemistry and ApplicationsCancer Mechanisms and Therapy