ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation
Zhuoyan Zai, Xuewen Qian, Yayun Xu, Huifang Lv, Mengjia Hao, Yueming Tao, Lixin Rui, Xiaoyue Zhang, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Abstract
Our study demonstrated that ASIC1a induces the destruction of articular cartilage through the disruption of the equilibrium between mitochondrial quality control and cell fate. This suggests that ASIC1a is a promising therapeutic target to improve the clinical treatment of RA.
Topics & Concepts
MitophagyCell biologySIRT3MitochondrionChemistryChondrocyteCartilageExtracellularDownregulation and upregulationmitochondrial fusionMFN2Programmed cell deathSynovial jointIntracellularPINK1CytoplasmArthritisBiologyOsteoarthritis Treatment and Mechanisms