Mechanistic insight into substrate processing and allosteric inhibition of human p97
Man Pan, Yuanyuan Yu, Huasong Ai, Qingyun Zheng, Yuan Xie, Lei Liu, Minglei Zhao
Topics & Concepts
Allosteric regulationConformational changeBiophysicsChemistryAAA proteinsMolecular machineProtein structureATPaseNucleotideCryo-electron microscopyPlasma protein bindingCell biologyStereochemistryBiochemistryBiologyEnzymeGeneticsGeneEndoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulationUbiquitin and proteasome pathways