Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells
Yolanda Salinas, Michael Kneidinger, Cristina Fornaguera, Salvador Borrós, Oliver Brüggemann, Ian Teasdale
Abstract
studies demonstrated the ability of these nanoparticles loaded with the drug camptothecin to be endocytosed in both models of tumor (A549) and healthy epithelial (BEAS-2B) lung cells. Their accumulation and the release of the chemotherapeutic drug, co-localized within lysosomes, was faster and higher for tumor than for healthy cells, further, the biocompatibility of PPz-gated nanosystem without drug was demonstrated. Tailored dual responsive polyphosphazenes thus represent novel and promising candidates in the construction of future gated mesoporous silica nanocarriers designs for lung cancer-directed treatment.
Topics & Concepts
NanocarriersChemistryPolyphosphazeneLower critical solution temperatureCamptothecinMesoporous silicaDrug deliveryNanoparticleBiophysicsPolymerNanotechnologyMaterials scienceMesoporous materialOrganic chemistryCopolymerBiologyCatalysisDendrimers and Hyperbranched PolymersLuminescence and Fluorescent MaterialsGraphene and Nanomaterials Applications