Electrochemical regioselective synthesis of sulfonyl 2,5-dihydrofuran-fused spiropyrimidines <i>via</i> multi-component radical cascade reactions
Qi-Liang Yang, Rong-Yi Xu, Chengyang Ni, Xin Liu, Zu-Lin Qiao, Qi-Ying Zhang, Dong‐Chao Wang, Hai‐Ming Guo
Abstract
In this work, we developed an efficient, eco-friendly electrochemical three-component one-pot method for the regioselective preparation of polysubstituted 2,5-dihydrofuran-fused spiropyrimidines with valuable –SO 2 R and –OR functional groups.
Topics & Concepts
SulfonylRegioselectivityCascadeChemistryElectrochemistryComponent (thermodynamics)Combinatorial chemistryCascade reactionOrganic chemistryCatalysisPhysical chemistryElectrodeChromatographyPhysicsAlkylThermodynamicsSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsMulticomponent Synthesis of Heterocycles