Use of Developmental Midazolam and 1-Hydroxymidazolam Data with Pediatric Physiologically Based Modeling to Assess Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyl Transferase 2B4 Ontogeny In Vivo
Trevor N. Johnson, Eleanor Howgate, Saskia N. de Wildt, M. Turner, Karen Rowland Yeo
Topics & Concepts
Cytochrome P450MidazolamIn vivoOntogenyUridineCYP3A4Uridine diphosphateIsozymeChemistryBiochemistryBiologyPharmacologyEnzymeEndocrinologyRNAGeneticsGeneSedationPharmacogenetics and Drug MetabolismPharmaceutical studies and practicesMetabolism and Genetic Disorders