A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide
Kaori Sato, Naoto Watamura, Ryo Fujioka, Naomi Mihira, Misaki Sekiguchi, Kenichi Nagata, Toshio Ohshima, Takashi Saito, Takaomi C. Saido, Hiroki Sasaguri
Abstract
mice and will help accelerate the development of disease-modifying therapies to treat preclinical AD.
Topics & Concepts
NeuroinflammationPSEN1PresenilinBiologyMutationAmyloid (mycology)PathologyGene knockinMutantDiseaseImmunologyAlzheimer's diseaseMedicineCancer researchInflammationGeneGeneticsAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsCholinesterase and Neurodegenerative Diseases