Phe–Phe-Based Macroscopic Supramolecular Hydrogel Construction Strategies and Biomedical Applications
Xiaoyang Liu, Qiaochu Jiang, Yun Yin, Gaolin Liang
Abstract
High Resolution Image Download MS PowerPoint Slide Since the phenylalanine (Phe) dipeptide moiety is referred to as an essential structure for building amyloid-β peptide from Alzheimer’s disease, its wonderful assembly ability to form nanofibers has been extensively studied. Cross-linked Phe–Phe-based peptide nanofibers can construct networks, thus encapsulating the drugs to form supramolecular hydrogels. Recently, scientists have proposed a variety of Phe–Phe-based macroscopic supramolecular hydrogels and used them in biomedical applications. Therefore, we summarize the construction strategies of Phe–Phe-based macroscopic supramolecular hydrogels and list their represented biomedical applications ( e.g., wound healing, eye protection, cancer therapy, etc. ) since the birth of Phe–Phe-based supramolecular hydrogels. In addition, we present the perspectives and challenges of Phe–Phe-based macroscopic peptide hydrogels.