Utilization of 1-phenylimidazo[1,5-<i>a</i>]quinoline as partner in 1,4-dipolar cycloaddition reactions
Areej M. Jaber, Jalal A. Zahra, Mustafa M. El‐Abadelah, Salim S. Sabri, Monther A. Khanfar, Wolfgang Voelter
Abstract
Abstract A Selected set of 2-(quinolin-2-yl)-1,3-oxazepino[7,6- b ]indoles 4a–d and dihydroacenaphtho[1,2- f ][1,3]oxazepine 5 have been prepared via 1,4-dipolar cycloaddition reaction involving 1-phenylimidazo[1,5- a ]quinoline, dimethyl acetylenedicarboxylate, and N -(substituted)isatins or acenaphthoquinone. Structures of the new heterocycles 4a–d and 5 are supported by NMR and HRMS spectral data, and confirmed by single-crystal X-ray crystallography for 4c and 5 .
Topics & Concepts
QuinolineCycloaddition1,3-Dipolar cycloadditionChemistryDimethyl acetylenedicarboxylateSingle crystalDipoleMedicinal chemistryComputational chemistryStereochemistryCrystallographyOrganic chemistryCatalysisMulticomponent Synthesis of HeterocyclesSynthesis and Biological EvaluationSynthesis and biological activity