Investigating the Roles of Listeria monocytogenes Peroxidases in Growth and Virulence
Monica R. Cesinger, Nicole H. Schwardt, Cortney R. Halsey, Maureen K. Thomason, Michelle L. Reniere
Abstract
Listeria monocytogenes is a facultative intracellular pathogen and the causative agent of the foodborne illness listeriosis. L. monocytogenes must contend with reactive oxygen species generated extracellularly during aerobic growth and intracellularly by the host immune system. However, the mechanisms by which L. monocytogenes defends against peroxide toxicity have not yet been defined. Here, we investigated the roles of each of the peroxidase-encoding genes in L. monocytogenes growth, peroxide stress response, and virulence in mammalian cells.
Topics & Concepts
Listeria monocytogenesMicrobiologyPeroxidaseBiologyPathogenVirulenceBacteriaIntracellular parasitePeroxideListeriaImmune systemReactive oxygen speciesListeria infectionEnzymeGeneBiochemistryChemistryImmunologyGeneticsOrganic chemistryListeria monocytogenes in Food SafetyAdvanced Nanomaterials in CatalysisEssential Oils and Antimicrobial Activity