Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
Ningning Wang, Chunyu Liu, Tian Wang, Yuelan Li, Ke Xu, Hong‐Xiang Lou
Abstract
Abstract Two new quinazoline derivatives versicomides E ( 1 ) and F ( 2 ), and 10 known compounds ( 3 – 12 ) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5 , 7 and 8 showed significant inhibitory effects on NO production, with IC 50 values of 49.85, 22.14 and 46.02 μM respectively. Graphic Abstract
Topics & Concepts
QuinazolineBioorganic chemistryNatural productFungusAspergillusMossChemistryAnti-inflammatoryAspergillus fumigatusStereochemistryBiologyMicrobiologyBiochemistryBotanyEnzymePharmacologyMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsPlant and fungal interactions