<i>De novo</i> design of type-l photosensitizer agents based on structure-inherent low triplet energy for hypoxia photodynamic therapy
Xiao‐Yun Ran, Wen-Li Xia, Lina Zhang, Xiao‐Qi Yu, Ping Chen, Kunpeng Xie, Yu Zhao, Yi Cheng, Kun Li
Abstract
Small-molecule of Type-I photosensitizers (PSs) based on dibenzofulvene were synthesized by lowering the triplet energy levels of the π-conjugation bridge and enhancing donor–acceptor interaction, showing excellent ROS production for anti-tumor.
Topics & Concepts
Photodynamic therapyHypoxia (environmental)PhotosensitizerCancer researchPhotochemistryMaterials scienceChemistryMedicineOxygenOrganic chemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies