Proline and dihydroorotate dehydrogenase promote a hyper-proliferative state and dampen ferroptosis in cancer cells by rewiring mitochondrial redox metabolism

Ryan J. Mailloux

2023Biochimica et Biophysica Acta (BBA) - Molecular Cell Research16 citationsDOI

Topics & Concepts

Dihydroorotate dehydrogenaseCell biologyMitochondrionCancer cellChemistryCell growthBiologyOxidative stressCarcinogenesisReactive oxygen speciesBiochemistryCancerEnzymeGeneGeneticsEpigenetics and DNA MethylationRNA modifications and cancerFerroptosis and cancer prognosis