Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity
Amad Uddin, Meenal Chawla, Iram Irfan, Shubhra Mahajan, Shailja Singh, Mohammad Abid
Abstract
. Based on the exhaustive literature reports, we have collated the structural and functional analyses of quinoline- and endoperoxide-based hybrid molecules that show potency equal to or greater than those of the individual compounds, offering an effective therapeutics option for clinical use.
Topics & Concepts
QuinolineMalariaPharmacologyChemistryAntimalarial AgentPlasmodium (life cycle)Drug resistancePlasmodium falciparumComputational biologyBiologyParasite hostingComputer scienceMicrobiologyImmunologyWorld Wide WebOrganic chemistryMalaria Research and ControlSynthesis and Catalytic ReactionsComputational Drug Discovery Methods